Journal article
The non-specific nature of mental health and structural brain outcomes following childhood trauma
Theresa K Haidl, Dennis M Hedderich, Marlene Rosen, Nathalie Kaiser, Mauro Seves, Thorsten Lichtenstein, Nora Penzel, Julian Wenzel, Lana Kambeitz-Ilankovic, Anne Ruef, David Popovic, Frauke Schultze-Lutter, Katharine Chisholm, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt Show all
PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2023
Abstract
Background Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by structural brain changes. Our aim was to explore whether (i) a predictive CT pattern for transdiagnostic psychopathology exists, and whether (ii) CT can differentiate between distinct diagnosis-dependent psychopathology. Furthermore, we aimed to identify the association between CT, psychopathology and brain structure. Methods We used multivariate pattern analysis in data from 643 participants of the Personalised Prognostic Tools for Early Psychosis Management study (PRONIA), i..
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Awarded by European Union
Awarded by Australian National Health & Medical Research Council (NHMRC)
Awarded by NHMRC
Awarded by DFG
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme under grant agreement no 602152. R.U. reports grants from Medical Research Council, grants from the National Institute for Health Research, and personal fees from Sunovion, outside the submitted work. N.K. and R.S. received honoraria for talks presented at education meetings organized by Otsuka/Lundbeck. C.P. participated in advisory boards for Janssen-Cilag, AstraZeneca, Lundbeck, and Servier and received honoraria for talks presented at educational meetings organized by AstraZeneca, Janssen-Cilag, Eli Lilly, Pfizer, Lundbeck, and Shire. C.P. acknowledges support by an Australian National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship (ID: 1105825), an NHMRC Program Grant (ID: 1150083). J.K. reports funding by the DFG (KA 4413/1-1) and received honoraria for talks presented at educational meetings organized by Janssen and Otsuka/Lundbeck. All other authors report no biomedical financial interests or potential conflicts of interest. The funding organizations stated above were not involved in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.